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Recent Posts
What are aromatics chemistry and exploring the fundamentals of aromatics chemistry ?
Chemical Testing in New Jersey – Pgsynth
Chiral Chemistry Definition and Examples
Processing and scale-up issues
4 Coupling reactions, all need flash column for isolation/purification.
Side-chain, tedious synthesis, difficult to make it pure.
One coupling reaction using DMTMM reagent, the reaction easily to be
stalled, requires adding more coupling reagent multiple time.
Final API, amorphous, extremely difficult to be purified, cp only 97%.
Total 9 + 2 = 11 steps, overall yield ~8%.